Fig. 1

Guidance of molecular biomarkers to glioma resection. The figure shows the recommended extent of resection for diffuse gliomas according to pathological grade and molecular biomarkers. The axial T2-weighted image and contrast-enhanced T1-weighted image presented four levels of EOR as follows: red, supra-total resection; orange, total resection; yellow, subtotal resection; and green, enhancing tissue resection. Supra-total resection is recommended for low-grade diffuse gliomas with IDH wild-type in the non-functional region; subtotal resection is recommended for diffuse gliomas with IDH mutation and 1p/19q codeletion in the functional region; enhancing tissue resection is recommended for anaplastic gliomas and glioblastomas with IDH wild-type; total resection is recommended for the remaining subtypes of diffuse gliomas. The recommended level is determined according to the Oxford Centre for Evidence-based Medicine Levels of Evidence